This program supports research on bone biology and clinical research on osteoporosis and metabolic bone disorders.

Bone biology & skeletal homeostasis studies include:

  • Osteoclasts, osteoblasts, and osteocytes in bone remodeling and mechanotransduction.
  • Signaling mechanisms mediating effects of hormones, growth factors, and cytokines in bone cells.
  • Bone matrix composition, structure, and function.
  • Pre-clinical development of novel therapeutics for osteoporosis.

Clinical studies in osteoporosis and metabolic bone disorders include:

  • Epidemiology, pathogenesis, and pathophysiology.
  • Environmental and genetic risk factors.
  • Treatment, prevention, and diagnosis.

Contact Us

D. Lee Alekel, Ph.D.

D. Lee Alekel, Ph.D.

Program Director
6701 Democracy Boulevard
Building: Democracy 1, Room: 858
Bethesda MD 20892-4872

Patient Registry

Funding Opportunities


Research news

The Division of Musculoskeletal Diseases supports research aimed at improving the diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system and its component tissues.

See all Scientific Areas in the Division of Musculoskeletal Diseases

Last Reviewed: