A young female doctor in a lab coat.

Contact Information

301-402-8228
9000 Rockville Pike
10 Center Drive
Building 10, 10N311
Bethesda MD 20892

Summary

Ecem Sevim, M.D. received her medical degree from Istanbul University, Cerrahpasa School of Medicine, in 2012. After three years of internal medicine residency experience in Istanbul, Turkey, Dr. Sevim moved to New York in 2017 to work as a research fellow at the Hospital for Special Surgery, NY. She spent a further two years there gaining extensive experience both in clinical and translational research. Dr. Sevim completed her internal medicine residency training at Albert Einstein College of Medicine/Montefiore Medical Center – Wakefield Campus and subsequently joined the NIAMS family for her clinical rheumatology fellowship.

Dr. Sevim has several publications in peer-reviewed journals. She has given numerous oral and poster presentations at venues such as the American College of Rheumatology and the International Congress of Internal Medicine.

Besides her engagement with rheumatology and research, her interests and hobbies include abstract art, jazz, snowboarding, yoga, and traveling.

Research Statement

Dr. Sevim is interested in studying antiphospholipid antibodies (aPL) and related clinical manifestations. Her primary focus is the pathogenesis of microvascular thrombosis related to autoimmune/autoinflammatory status.

She previously worked as a research fellow for the international consortium AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION). She participated in the development of a flow cytometry-based assay for mammalian target of rapamycin (mTOR) activation in peripheral blood. She also investigated cell signaling pathways in autoimmune diseases, specifically the role of mTOR pathway activation in the skin biopsies of aPL-positive patients with livedo.

Dr. Sevim currently works in the Laboratory of Vascular Thrombosis and Inflammation, led by Dr. Yogen Kanthi, focusing on identifying the molecular and cellular processes in antiphospholipid antibody-positive patients that lead to disease manifestations in the view of thrombo-inflammation.

Scientific Publications

Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry').

Erton ZB, Sevim E, de Jesús GR, Cervera R, Ji L, Pengo V, Ugarte A, Andrade D, Andreoli L, Atsumi T, Fortin PR, Gerosa M, Zuo Y, Petri M, Sciascia S, Tektonidou MG, Aguirre-Zamorano MA, Branch DW, Erkan D, APS ACTION
Lupus Sci Med.
2022 Jun;
9(1).
doi: 10.1136/lupus-2021-000633
PMID: 35701043

Mammalian Target of Rapamycin Pathway Assessment in Antiphospholipid Antibody-Positive Patients with Livedo.

Sevim E, Siddique S, Chalasani MLS, Chyou S, Shipman WD, O'Shea O, Harp J, Alpan O, Zuily S, Lu TT, Erkan D
J Rheumatol.
2022 Sep;
49(9).
doi: 10.3899/jrheum.220049
PMID: 35649551

The Psychosocial Impact of Undifferentiated Connective Tissue Disease on Patient Health and Well-Being: A Qualitative Study.

Siegel CH, Kleinman J, Barbhaiya M, Sevim E, Vega J, Mancuso CA, Lockshin MD, Sammaritano LR
J Clin Rheumatol.
2022 Mar 1;
28(2).
doi: 10.1097/RHU.0000000000001714
PMID: 33657588

The Relationship Between Osteoarthritis and Sarcopenia in Geriatric Diabetic Patients.

Basat S, Sivritepe R, Ortaboz D, Sevim E, Atay S, Baygul A
Sisli Etfal Hastan Tip Bul.
2021;
55(4).
doi: 10.14744/SEMB.2021.42890
PMID: 35317381

Antiphospholipid Antibody Profile Stability Over Time: Prospective Results From the APS ACTION Clinical Database and Repository.

Gkrouzman E, Sevim E, Finik J, Andrade D, Pengo V, Sciascia S, Tektonidou MG, Ugarte A, Chighizola CB, Belmont HM, Lopez-Pedrera C, Ji L, Fortin P, Efthymiou M, de Jesus GR, Branch DW, Nalli C, Petri M, Rodriguez E, Cervera R, Knight JS, Atsumi T, Willis R, Bertolaccini ML, Cohen H, Rand J, Erkan D, APS ACTION+
J Rheumatol.
2021 Apr;
48(4).
doi: 10.3899/jrheum.200513
PMID: 33259328

Characteristics of Patients With Antiphospholipid Antibody Positivity in the APS ACTION International Clinical Database and Repository.

Sevim E, Zisa D, Andrade D, Sciascia S, Pengo V, Tektonidou MG, Ugarte A, Gerosa M, Belmont HM, Zamorano MAA, Fortin PR, Ji L, Efthymiou M, Cohen H, Branch DW, de Jesus GR, Andreoli L, Petri M, Rodriguez E, Cervera R, Knight JS, Atsumi T, Willis R, Roubey R, Bertolaccini ML, Erkan D, Barbhaiya M, APS ACTION Investigators
Arthritis Care Res (Hoboken).
2022 Feb;
74(2).
doi: 10.1002/acr.24468
PMID: 32986935

Is there a role for immunosuppression in antiphospholipid syndrome?

Sevim E, Willis R, Erkan D
Hematology Am Soc Hematol Educ Program.
2019 Dec 6;
2019(1).
doi: 10.1182/hematology.2019000073
PMID: 31808842

Impact of antiphospholipid syndrome iBook on medical students' improvement of knowledge: An international randomized controlled study.

Zuily S, Phialy L, Sevim E, Germain E, Unlu O, Dufrost V, Risse J, Clerc-Urmès I, Baumann C, Berman JR, Lockshin MD, Wahl D, Erkan D
Eur J Rheumatol.
2019 Oct;
6(4).
doi: 10.5152/eurjrheum.2019.19030
PMID: 31657703

Comparison of real world and core laboratory lupus anticoagulant results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) clinical database and repository.

Efthymiou M, Mackie IJ, Lane PJ, Andrade D, Willis R, Erkan D, Sciascia S, Krillis S, Bison E, Borges Galhardo Vendramini M, Romay-Penabad Z, Qi M, Tektonidou M, Ugarte A, Chighizola C, Belmont HM, Aguirre MA, Ji L, Branch DW, de Jesus G, Fortin PR, Andreoli L, Petri M, Cervera R, Rodriguez E, Knight JS, Atsumi T, Vega J, Sevim E, Bertolaccini ML, Pengo V, Cohen H, APS ACTION
J Thromb Haemost.
2019 Dec;
17(12).
doi: 10.1111/jth.14596
PMID: 31364274

The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort.

Radin M, Sciascia S, Erkan D, Pengo V, Tektonidou MG, Ugarte A, Meroni P, Ji L, Belmont HM, Cohen H, Ramires de Jesús G, Branch DW, Fortin PR, Andreoli L, Petri M, Rodriguez E, Rodriguez-Pinto I, Knight JS, Atsumi T, Willis R, Gonzalez E, Lopez-Pedrera R, Rossi Gandara AP, Borges Gualhardo Vendramini M, Banzato A, Sevim E, Barbhaiya M, Efthymiou M, Mackie I, Bertolaccini ML, Andrade D, APS ACTION
Semin Arthritis Rheum.
2019 Dec;
49(3).
doi: 10.1016/j.semarthrit.2019.04.009
PMID: 31153708

Education

Istanbul University, Cerrahpasa School of Medicine, Istanbul – Turkey
MD (2012)

Experience

Residency – Internal Medicine
Montefiore Medical Center, Wakefield Campus, NY (2019-2022)

Research Fellowship - Rheumatology
Hospital for Special Surgery, NY (2017-2019)

Residency – Internal Medicine
Health Sciences University, Umraniye Training and Research Hospital, Istanbul – Turkey (2013-2017)

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