Lily Dai, M.D., Vasculitis Translational Research Program, NIAMS

Contact Information

9000 Rockville Pike

10 Center Drive

Building 10, Room 12S-253

Bethesda MD 20892

dailz@mail.nih.gov

Summary

Dr. Dai has a strong background in biology, immunology, microbiology, vaccinology, biochemistry, and clinical trials. She is skilled in using animal models and biological assays as well as flow cytometry and PCR. Her research experience includes DNA, RNA, and protein/polysaccharide purification and quantitation as well as human cell-line culture, PBMC/PMN isolation and differentiation, and antibody production. She is also proficient in sample preparation for flow cytometry, barcoding bio-specimens, vaccine characterization and proficiency evaluation, and GMP procedures.

Research Statement

Dr. Dai’s current research focus is to characterize the immunologic aspects of vasculitis and relapsing polychondritis. She is involved in translational research related to the molecular classification of disease.

Previously, Dr. Dai studied vaccine development for TB and other diseases at the NICHD. She worked with bacterial pathogens and monoclonal antibodies for human use in addition to developing polysaccharide conjugate vaccines against bacterial infectious diseases for preclinical and clinical trials.

Scientific Publications

Effects of infection and disease with Mycobacterium tuberculosis on serum antibody to glucan and arabinomannan: two surface polysaccharides of this pathogen.

Keitel WA, Dai Z, Awe RW, Atmar RL, Morris S, Schneerson R, Robbins JB

BMC Infect Dis.

2013 Jun 19;

13().

doi: 10.1186/1471-2334-13-276

PMID: 23783070

Bacillus anthracis Capsular Conjugates Elicit Chimpanzee Polyclonal Antibodies That Protect Mice from Pulmonary Anthrax.

Chen Z, Schneerson R, Lovchik JA, Dai Z, Kubler-Kielb J, Agulto L, Leppla SH, Purcell RH

Clin Vaccine Immunol.

2015 Aug;

22(8).

doi: 10.1128/CVI.00137-15

PMID: 26041039

Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule.

Chen Z, Schneerson R, Lovchik J, Lyons CR, Zhao H, Dai Z, Kubler-Kielb J, Leppla SH, Purcell RH

Proc Natl Acad Sci U S A.

2011 Jan 11;

108(2).

doi: 10.1073/pnas.1017677108

PMID: 21187383

Antigenic evidence of prevalence and diversity of Mycobacterium tuberculosis arabinomannan.

Glatman-Freedman A, Casadevall A, Dai Z, Jacobs WR Jr, Li A, Morris SL, Navoa JA, Piperdi S, Robbins JB, Schneerson R, Schwebach JR, Shapiro M

J Clin Microbiol.

2004 Jul;

42(7).

Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine.

Schneerson R, Kubler-Kielb J, Liu TY, Dai ZD, Leppla SH, Yergey A, Backlund P, Shiloach J, Majadly F, Robbins JB

Proc Natl Acad Sci U S A.

2003 Jul 22;

100(15).

Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan.

Navoa JA, Laal S, Pirofski LA, McLean GR, Dai Z, Robbins JB, Schneerson R, Casadevall A, Glatman-Freedman A

Clin Diagn Lab Immunol.

2003 Jan;

10(1).

Glucan is a component of the Mycobacterium tuberculosis surface that is expressed in vitro and in vivo.

Schwebach JR, Glatman-Freedman A, Gunther-Cummins L, Dai Z, Robbins JB, Schneerson R, Casadevall A

Infect Immun.

2002 May;

70(5).

Expression of a Mycobacterium tuberculosis arabinomannan antigen in vitro and in vivo.

Schwebach JR, Casadevall A, Schneerson R, Dai Z, Wang X, Robbins JB, Glatman-Freedman A

Infect Immun.

2001 Sep;

69(9).

Education

Capital Institute of Pediatrics, Beijing , China
M.D. (equivalent in US) Pediatrics

Peking Union Medical College, Beijing, China
M.Sc. Microbiology & Immunology

Capital Medical University, Beijing, China
B.S. Medicine

Experience

Biologist
LCMI NIAID NIH, Bethesda MD (2019-2020)

Medical Interpreter
Liberty Language Services, VA (2015-2020)

Research Scientist
PDMI NICHD,NIH, Bethesda MD (1997-2013)

Visiting Fellow
PDMI NICHD,NIH, Bethesda MD (1993-1996)