Summary

Maria Casal-Dominguez, M.D., Ph.D., is a Research Fellow at the Muscle Disease Section of the NIAMS (NIH). She began at the NIH as a Postdoctoral Fellow in 2016 and attained her current position in 2020. Previously, Dr. Casal-Dominguez worked as a Research Fellow at the Rheumatology Department of the Johns Hopkins Hospital.

Dr. Casal-Dominguez graduated from Santiago de Compostela School of Medicine and completed her Family Medicine Residency training at the Mar Hospital and the Clot Primary Care Centre in Barcelona. She earned her Ph.D. in Medicine and Translational Research from the University of Barcelona.

Her research is focused on understanding the pathophysiology of autoimmune myositis.

Research Statement

Dr. Casal-Dominguez's major areas of research are immunology and rheumatology, especially the understanding of the pathophysiology of autoimmune myositis. To investigate these topics, she is using next generation sequencing techniques, data science, and bioinformatics. 

Scientific Publications

The indirect immunofluorescence assay autoantibody profiles of myositis patients without known myositis-specific autoantibodies.

Casal-Dominguez M, Pinal-Fernandez I, Pak K, Marin-Sanchez A, Sanz-Martinez MT, Baucells A, Hosono Y, Christopher-Stine L, Mammen AL, Johns Hopkins Myositis Center Group
Clin Exp Rheumatol.
2021 May-Jun;
39(3).
doi: 10.55563/clinexprheumatol/7kyr5e
PMID: 32896249

Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis.

Pinal-Fernandez I, Casal-Dominguez M, Derfoul A, Pak K, Miller FW, Milisenda JC, Grau-Junyent JM, Selva-O'Callaghan A, Carrion-Ribas C, Paik JJ, Albayda J, Christopher-Stine L, Lloyd TE, Corse AM, Mammen AL
Ann Rheum Dis.
2020 Sep;
79(9).
doi: 10.1136/annrheumdis-2019-216599
PMID: 32546599

Validation of anti-Mi2 autoantibody testing by line blot.

Pinal-Fernandez I, Pak K, Casal-Dominguez M, Hosono Y, Mecoli C, Christopher-Stine L, Mammen AL
Autoimmun Rev.
2020 Jan;
19(1).
doi: 10.1016/j.autrev.2019.102425
PMID: 31734399

Identification of distinctive interferon gene signatures in different types of myositis.

Pinal-Fernandez I, Casal-Dominguez M, Derfoul A, Pak K, Plotz P, Miller FW, Milisenda JC, Grau-Junyent JM, Selva-O'Callaghan A, Paik J, Albayda J, Christopher-Stine L, Lloyd TE, Corse AM, Mammen AL
Neurology.
2019 Sep 17;
93(12).
doi: 10.1212/WNL.0000000000008128
PMID: 31434690

Identification of distinctive interferon gene signatures in different types of myositis.

Pinal-Fernandez I, Casal-Dominguez M, Derfoul A, Pak K, Plotz P, Miller FW, Milisenda JC, Grau-Junyent JM, Selva-O'Callaghan A, Paik J, Albayda J, Christopher-Stine L, Lloyd TE, Corse AM, Mammen AL
Neurology.
2019 Sep 17;
93(12).
doi: 10.1212/WNL.0000000000008128
PMID: 31434690

Long-Term Treatment With Azathioprine and Mycophenolate Mofetil for Myositis-Related Interstitial Lung Disease.

Huapaya JA, Silhan L, Pinal-Fernandez I, Casal-Dominguez M, Johnson C, Albayda J, Paik JJ, Sanyal A, Mammen AL, Christopher-Stine L, Danoff SK
Chest.
2019 Nov;
156(5).
doi: 10.1016/j.chest.2019.05.023
PMID: 31238042

Efficacy and adverse effects of methotrexate compared with azathioprine in the antisynthetase syndrome.

Casal-Dominguez M, Pinal-Fernandez I, Huapaya J, Albayda J, Paik JJ, Johnson C, Silhan L, Mammen AL, Danoff SK, Christopher-Stine L
Clin Exp Rheumatol.
2019 Sep-Oct;
37(5).

Muscular and extramuscular features of myositis patients with anti-U1-RNP autoantibodies.

Casal-Dominguez M, Pinal-Fernandez I, Corse AM, Paik J, Albayda J, Casciola-Rosen L, Johnson C, Danoff SK, Christopher-Stine L, Tiniakou E, Mammen AL
Neurology.
2019 Mar 26;
92(13).
doi: 10.1212/WNL.0000000000007188
PMID: 30824556

Education

University of Barcelona, Spain
Ph.D., Medicine and Translational Research (2018)

Hospital del Mar, Barcelona, Spain
Family Medicine Residency (2011-2015)

Santiago de Compostela Medical School, Spain
Medical Degree (2010)

Experience

Research Fellow
NIH, NIAMS (May 2020-present)

Postdoctoral Fellow (Visiting)
NIH, NIAMS (2016-April 2020)

Research Fellow
Johns Hopkins Hospital, Rheumatology Department (2015-2016)

Family Medicine Resident
Hospital del Mar, Barcelona, Spain (2011-2015)

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