Pawel Trzaskoma, Ph.D.

Contact Information

301-435-3052
9000 Rockville Pike
10 Center Drive
Building 10, Room 13C120
Bethesda MD 20892

Summary

Pawel Trzaskoma earned his Ph.D. in cell biology in 2019. He is interested in microscopy, 3D chromatin organization, and its role in gene transcription.

Scientific Publications

Activation-induced chromatin reorganization in neurons depends on HDAC1 activity.

Grabowska A, Sas-Nowosielska H, Wojtas B, Holm-Kaczmarek D, Januszewicz E, Yushkevich Y, Czaban I, Trzaskoma P, Krawczyk K, Gielniewski B, Martin-Gonzalez A, Filipkowski RK, Olszynski KH, Bernas T, Szczepankiewicz AA, Sliwinska MA, Kanhema T, Bramham CR, Bokota G, Plewczynski D, Wilczynski GM, Magalska A
Cell Rep.
2022 Feb 15;
38(7).
doi: 10.1016/j.celrep.2022.110352
PMID: 35172152

PartSeg: a tool for quantitative feature extraction from 3D microscopy images for dummies.

Bokota G, Sroka J, Basu S, Das N, Trzaskoma P, Yushkevich Y, Grabowska A, Magalska A, Plewczynski D
BMC Bioinformatics.
2021 Feb 17;
22(1).
doi: 10.1186/s12859-021-03984-1
PMID: 33596823

Colocalization Colormap -an ImageJ Plugin for the Quantification and Visualization of Colocalized Signals.

Gorlewicz A, Krawczyk K, Szczepankiewicz AA, Trzaskoma P, Mulle C, Wilczynski GM
Neuroinformatics.
2020 Oct;
18(4).
doi: 10.1007/s12021-020-09465-9
PMID: 32361813

Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization.

Trzaskoma P, Ruszczycki B, Lee B, Pels KK, Krawczyk K, Bokota G, Szczepankiewicz AA, Aaron J, Walczak A, Śliwińska MA, Magalska A, Kadlof M, Wolny A, Parteka Z, Arabasz S, Kiss-Arabasz M, Plewczyński D, Ruan Y, Wilczyński GM
Nat Commun.
2020 May 1;
11(1).
doi: 10.1038/s41467-020-15987-2
PMID: 32358536

Blank spots on the map: some current questions on nuclear organization and genome architecture.

Adriaens C, Serebryannyy LA, Feric M, Schibler A, Meaburn KJ, Kubben N, Trzaskoma P, Shachar S, Vidak S, Finn EH, Sood V, Pegoraro G, Misteli T
Histochem Cell Biol.
2018 Dec;
150(6).
doi: 10.1007/s00418-018-1726-1
PMID: 30238154

Pericardium: structure and function in health and disease.

Jaworska-Wilczynska M, Trzaskoma P, Szczepankiewicz AA, Hryniewiecki T
Folia Histochem Cytobiol.
2016;
54(3).
doi: 10.5603/FHC.a2016.0014
PMID: 27654013

CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription.

Tang Z, Luo OJ, Li X, Zheng M, Zhu JJ, Szalaj P, Trzaskoma P, Magalska A, Wlodarczyk J, Ruszczycki B, Michalski P, Piecuch E, Wang P, Wang D, Tian SZ, Penrad-Mobayed M, Sachs LM, Ruan X, Wei CL, Liu ET, Wilczynski GM, Plewczynski D, Li G, Ruan Y
Cell.
2015 Dec 17;
163(7).
doi: 10.1016/j.cell.2015.11.024
PMID: 26686651

The biphasic interphase-mitotic polarity of cell nuclei induced under DNA replication stress seems to be correlated with Pin2 localization in root meristems of Allium cepa.

Żabka A, Trzaskoma P, Winnicki K, Polit JT, Chmielnicka A, Maszewski J
J Plant Physiol.
2015 Feb 1;
174().
doi: 10.1016/j.jplph.2014.09.013
PMID: 25462968

CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi.

Skupien A, Konopka A, Trzaskoma P, Labus J, Gorlewicz A, Swiech L, Babraj M, Dolezyczek H, Figiel I, Ponimaskin E, Wlodarczyk J, Jaworski J, Wilczynski GM, Dzwonek J
J Cell Sci.
2014 Dec 1;
127(Pt 23).
doi: 10.1242/jcs.154542
PMID: 25300795

Dissimilar effects of β-lapachone- and hydroxyurea-induced DNA replication stress in root meristem cells of Allium cepa.

Zabka A, Trzaskoma P, Maszewski J
Plant Physiol Biochem.
2013 Dec;
73().
doi: 10.1016/j.plaphy.2013.10.001
PMID: 24184448

Education

Nencki Institute of Experimental Biology, Polish Academy of Sciences (PAS)
Ph.D., Cell Biology (2019)

University of Warsaw
M.Sc., Molecular Biotechnology (2014)

University of Lodz
B.Sc., Biotechnology (2012)

Experience

Postdoctoral Fellow
NIH/NIAMS (2019-present)

Ph.D. Student 
Nencki Institute, PAS (2014-2019)

Special Volunteer
NIH/NCI (2018)

Short Term Visitor 
Advanced Imaging Center, Janelia Research Campus HHMI (2016)

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