The program supports three primary research areas: clinical osteoarthritis; bone quality and skeletal imaging; and human genetics of bone and cartilage. Within each of these portfolio areas, studies emphasize the following:
Clinical osteoarthritis and the Osteoarthritis Initiative:
- Epidemiology and pathogenesis of osteoarthritis.
- Physical, environmental and genetic risk factors for osteoarthritis.
- Treatment, prevention, and diagnosis of osteoarthritis.
- Novel imaging methods for cartilage and joints.
Bone quality and skeletal imaging:
- In vivo methods for macro and micro scale imaging of bone.
- Architecture and mechanical properties of bone.
- Multi-scale modeling of the human bone.
- Assessment of bone quality.
- Clinical studies related to bone strength and density.
Human genetics of bone and cartilage:
- Genetic/genomic epidemiology.
- Gene discovery and high throughput technologies.
- Gene-environment interactions.