Stefania Dell'Orso, Ph.D. , Genomic Technology Section, Office of Science and Technology, NIAMS

Contact Information

301-451-9544

9000 Rockville Pike

Building 50, Room 1345

Bethesda MD 20892

dellorsos@mail.nih.gov

Media Resources

High Resolution Image

stefania-dell-orso.jpg

Summary

Dr. Dell’Orso received her Ph.D. from the University of Rome in Italy and conducted her post-doc research at the NIAMS where she focused on the role of transcription factors, chromatin regulators, ncRNAs and epigenetic marks during skeletal muscle specification and development. In 2016 she joined the NIAMS Genomic Technology Section where she provides consultation on experimental design and library preparation and works with NIAMS scientists to implement genomics and sequencing technologies.

Research Statement

The Genomic Technology Section at NIAMS is a multi-disciplinary genomics facility that supports NIAMS investigators with the latest on DNA sequencing and library preparation technologies. The Section works closely with NIAMS scientists to explore the use and implementation of leading edge genomics technologies, molecular biology protocols and analytical procedures as well as consultation and training for researchers with specific needs or challenging problems.

Scientific Publications

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC

N Engl J Med.

2020 Dec 31;

383(27).

doi: 10.1056/NEJMoa2026834

PMID: 33108101

FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age.

García-Prat L, Perdiguero E, Alonso-Martín S, Dell'Orso S, Ravichandran S, Brooks SR, Juan AH, Campanario S, Jiang K, Hong X, Ortet L, Ruiz-Bonilla V, Flández M, Moiseeva V, Rebollo E, Jardí M, Sun HW, Musarò A, Sandri M, Del Sol A, Sartorelli V, Muñoz-Cánoves P

Nat Cell Biol.

2020 Nov;

22(11).

doi: 10.1038/s41556-020-00593-7

PMID: 33106654

A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V

Mol Cell.

2018 Jul 5;

71(1).

doi: 10.1016/j.molcel.2018.06.008

PMID: 29979962

Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus.

Carlucci PM, Purmalek MM, Dey AK, Temesgen-Oyelakin Y, Sakhardande S, Joshi AA, Lerman JB, Fike A, Davis M, Chung JH, Playford MP, Naqi M, Mistry P, Gutierrez-Cruz G, Dell'Orso S, Naz F, Salahuddin T, Natarajan B, Manna Z, Tsai WL, Gupta S, Grayson P, Teague H, Chen MY, Sun HW, Hasni S, Mehta NN, Kaplan MJ

JCI Insight.

2018 Apr 19;

3(8).

pii: 99276. doi: 10.1172/jci.insight.99276

PMID: 29669944

The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.

Wang AH, Juan AH, Ko KD, Tsai PF, Zare H, Dell'Orso S, Sartorelli V

Mol Cell.

2017 Oct 19;

68(2).

doi: 10.1016/j.molcel.2017.09.016

PMID: 29033324

Laminopathies disrupt epigenomic developmental programs and cell fate.

Perovanovic J, Dell'Orso S, Gnochi VF, Jaiswal JK, Sartorelli V, Vigouroux C, Mamchaoui K, Mouly V, Bonne G, Hoffman EP

Sci Transl Med.

2016 Apr 20;

8(335).

doi: 10.1126/scitranslmed.aad4991

PMID: 27099177

The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1.

Dell'Orso S, Wang AH, Shih HY, Saso K, Berghella L, Gutierrez-Cruz G, Ladurner AG, O'Shea JJ, Sartorelli V, Zare H

Cell Rep.

2016 Feb 9;

14(5).

doi: 10.1016/j.celrep.2015.12.103

PMID: 26832413

The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells.

Ryall JG, Dell'Orso S, Derfoul A, Juan A, Zare H, Feng X, Clermont D, Koulnis M, Gutierrez-Cruz G, Fulco M, Sartorelli V

Cell Stem Cell.

2015 Feb 5;

16(2).

doi: 10.1016/j.stem.2014.12.004

PMID: 25600643

Education

University of “La Sapienza”, Rome, Italy

Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH

Experience

Chief
Genomic Technology Section, OST, NIAMS, NIH

Senior Staff Scientist
Genomic Technology Section, OST, NIAMS, NIH

Research Fellow
Genomic Technology Section, OST, NIAMS, NIH

Post-doc
Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH