Dr. Che's research at HKU centered around the problem of the environmental dimension of antimicrobial resistance. He employed interdisciplinary approaches of NGS (Nanopore sequencing), bioinformatics, and molecular techniques to understand the transfer mechanisms and evolutionary process in shaping the dissemination of resistance and the emergence and development of multidrug-resistant pathogens.

His current research interest is investigating the skin microbes in patients and healthy volunteers. He is particularly interested in studying the interactions between microbiota and immunity in primary immunodeficiency patients.