The Cutaneous Microbiome and Inflammation section is focused on studying the skin microbiome in healthy individuals with the goal of expanding our understanding of host-microbe interactions. Previous work has investigated the diversity and distrubution of bacterial and fungal skin communities in healthy adults.
We are also working to understand the role of microbes in eczematous skin diseases, including atopic dermatitis. Our prior work has studied the significant bacterial shifts in the skin of patients with atopic dermatitis as well as patients with primary immunodeficiency syndromes with eczematous skin conditions.
- Studies of Dermatologic Diseases-Biospecimen Acquisition Protocol
- Effects of Antimicrobial Treatments on the Microbiome in Healthy Volunteers and Patients with Atopic Dermatitis
- The Acquisition of Blood and Skin Samples from Patient Volunteers to Support Research Activities on Dermatologic and Other Diseases
Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA. Topographical and temporal diversity of the human skin microbiome. Science. 324: 1190-2, 2009.
Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, Murray PR, Turner ML, Segre JA. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 22: 850-9, 2012.
Oh J, Conlan S, Polley EC, Segre JA, Kong HH. Shifts in human skin and nares microbiota of healthy children and adults. Genome Med. 4: 77, 2012.
Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, Schoenfeld D, Nomicos E, Park M, Kong HH, Segre JA. Topographic diversity of fungal and bacterial communities in human skin. Nature. 498: 367-70, 2013.
Oh J, Freeman AF, Park M, Sokolic R, Candotti F, Holland SM, Segre JA, Kong HH. The altered landscape of the human skin microbiome in patients with primary immunodeficiencies. Genome Res. 23: 2103-14, 2013.
Byrd AL, Deming C, Cassidy SKB, Harrison OJ , Ng W-I, Conlan S, NISC Comparative Sequencing Program, Belkaid Y, Segre JA*, Kong HH*. (2017) Staphylococcus aureus and S. epidermidis strain diversity underlying human atopic dermatitis. Sci Transl Med. 9:eeal4651 PMID 28679656 *denotes co-senior author
Oh J^, Byrd A^, Park M, NISC, Kong HH*, Segre JA*. (2016) Temporal Stability of the Human Skin Microbiome. Cell. 165:854-66. PMID 27153496 ^denotes co-first author *denotes co-senior author
Jo JH, Deming C, Kennedy EA, Conlan S, Polley EC, Ng WL, NISC Comparative Sequencing Program, Segre JA*, Kong HH*. (2016) Diverse human skin fungal communities in children converge in adulthood. J Invest Dermatol. 136:2356-2363 PMID 27476723 *denotes co-senior author
Oh J, Byrd AL, Deming C, Conlan S, NISC Comparative Sequencing Program, Kong HH*, Segre JA*. (2014) Biogeography and individuality shape function in the human skin metagenome. Nature. 514: 59-64. PMID 25279917 *denotes equal contribution
Findley K, Oh J, Yang J, Conlan S, Deming C, Meyer JA, Schoenfeld D, Nomicos E, Park M, NISC, Kong HH*, Segre JA* (2013): Topographic diversity of fungal and bacterial communities in human skin. Nature. 498(7454):367-70. PMID 23698366. *denotes equal contribution