Research Progress Related to Ankylosing Spondylitis

The NIAMS conducts translational and clinical research on the causes and treatment of ankylosing spondylitis.

Over the last several decades, NIAMS-funded research has greatly increased our understanding of genetics and ankylosing spondylitis, including:

• The discovery of the relationship between ankylosing spondylitis and the HLA-B27 gene, the primary gene involved in the development of the disease.
• The discovery of genes and genetic markers that help scientists understand more about how ankylosing spondylitis develops. These findings can help researchers develop more effective treatments.
• Genetic influences that are associated with risk for ankylosing spondylitis.

Current research focuses on investigating:

• Genetic factors and risks that may influence the severity of the disease.
• How alterations and changes in the immune system are associated with the development of ankylosing spondylitis.
• How the environment and genetics interact and affect the course of the disease.
• How to optimize imaging to evaluate disease at diagnosis as well as to assess progression.
• If computed tomography (CT) scanning can help monitor the disease.
• New and current medications to treat the disease more effectively.
• Evaluation and management of disease that starts in childhood.