In this report, researchers described a deep neural generative framework, the dynamic batching adversarial autoencoder (DB-AAE), which excels at denoising scRNA-seq datasets. DB-AAE directly captures optimal features from input data and enhances feature preservation, including cell type-specific gene expression patterns.

Scientists at NIAMS and the National Cancer Institute have identified a new clue to the diagnosis of BAP1 TPDS through a study at the NIH Clinical Center in Bethesda, Maryland. Individuals with known mutations in the BAP1gene were enrolled in the study and evaluated for nail abnormalities.

Testing for MAA may be clinically useful in children with myositis. Given the association between MAA and severe disease, children with myositis who have one or more MAA types may need to receive more aggressive treatment than those without these autoantibodies.

Findings from this study provide additional knowledge about the different species and subspecies of staphylococci that live on the human skin and how these different types of bacteria have adapted to varied skin areas.

This case report is the first description of topical ruxolitinib—a JAK inhibitor—improving skin rash in two patients with JDM or DM who did not improve with other treatments.

Neutrophils are essential first responders in the immune system, playing a significant role in various diseases. This method will be helpful in neutrophil-targeted drug development by offering real-time, high-throughput screening.

RNA binding proteins (RBPs) are a large and diverse class of proteins. They are encoded by more than 1,500 genes in humans. RBPs control every aspect of RNA metabolism and posttranscriptionally regulate gene expression. However, identifying RBPs is challenging because many of them lack clearly identifiable features and are involved in processes not necessarily thought to be RNA related, such as metabolism (all the chemical changes that occur in a cell to break down a molecule).

Clonal hematopoiesis is a term to describe a process where healthy individuals acquire genetic mutations in their blood cells later in life. Cells that carry these mutations promote inflammation, which increases risk of death due to cardiovascular disease.

Merkel cell carcinoma is an aggressive skin cancer that occurs when nerve-like cells that produce hormones (called neuroendocrine cells) grow out of control. The disease is rare in people under age 50. Genetic screenings of people with early onset Merkel cell carcinoma show that 19 percent had well-described variants in genes associated with an increased likelihood of cancer development.

New research from NIAMS and NIAID indicates that preventive medicine and musculoskeletal interventions have important economic benefits. Using decades of data on health and income, researchers showed that faster walking speeds and mobility are strongly associated with higher income.